Endocrine Abstracts

A breakdown in stromal-epithelial interactions mediated by androgens is emerging as a key factor in prostate cancer (PCa) aetiology and progression. Currently however, we have limited knowledge of the mechanics of androgen and androgen receptor (AR) action in prostate stroma, or how dysfunction in that compartment contributes to the disease process.In this study, immunohistochemical analysis of 64 PCa samples revealed an inverse relationship between stro...

Background: Serum thyroglobulin (Tg) measurements are one of the main pillars of thyroid cancer follow-up, because of the high organ and disease specificity of Tg in athyrotic patients. However, 20–25% of patients have detectable serum anti-Tg auto-antibodies (TgAB), which might cause false low Tg measurements in immunometric assays (IMA). This can lead to significant challenges in patient management. Measurement of Tg by liquid chromatography-tandem mass spectrometry (LC...

Thyroid physiology in early pregnancy is characterised by an increase of thyroxine binding globulin. This has been taken into account when using total T4 (TT4) if a ‘T3 uptake test (TUp)’ is used to derive the FTI. The American Thyroid Association Guidelines (1990) recommend ceasing the use of uptake tests, although in the USA they are still widely used. The aim of this study is to compare the TT4 and TUp to the FT4 in early gestation. TT4, TUp, FT4 and TSH were meas...

Introduction: Multi-modal therapy for adrenocortical carcinoma (ACC) includes surgery, therapy with the adrenolytic agent mitotane and systemic chemotherapy. Achievement of therapeutic mitotane concentrations (≥14 mg/l) has been related to improved outcomes.Aim: To evaluate the effectiveness of a defined* high dose protocol mitotane therapy in patients with advanced ACC (stages III and IV).Methods: Review of patients presenti...